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Biophys J. 2008 Jan 15;94(2):359-65. Epub 2007 Oct 19.

Coupled feedback loops form dynamic motifs of cellular networks.

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1
Department of Bio and Brain Engineering and KI for the BioCentury, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon, Republic of Korea.

Abstract

Cellular networks are composed of complicated interconnections among components, and some subnetworks of particular functioning are often identified as network motifs. Among such network motifs, feedback loops are thought to play important dynamical roles. Intriguingly, such feedback loops are very often found as a coupled structure in cellular circuits. Therefore, we integrated all the scattered information regarding the coupled feedbacks in various cellular circuits and investigated the dynamical role of each coupled structure. Finally, we discovered that coupled positive feedbacks enhance signal amplification and bistable characteristics; coupled negative feedbacks realize enhanced homeostasis; coupled positive and negative feedbacks enable reliable decision-making by properly modulating signal responses and effectively dealing with noise.

PMID:
17951298
PMCID:
PMC2157222
DOI:
10.1529/biophysj.107.105106
[Indexed for MEDLINE]
Free PMC Article
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