Anticancer and anti-inflammatory activities of 1,8-naphthyridine-3-carboxamide derivatives

Bioorg Med Chem Lett. 2007 Dec 1;17(23):6660-4. doi: 10.1016/j.bmcl.2007.08.006. Epub 2007 Aug 11.

Abstract

Several 1,8-naphthyridine-3-carboxamide derivatives (8-23) were synthesized and tested for in vitro cytotoxicity against eight cancer cell lines and a normal cell line. Compound 12 exhibited high cytotoxicity (IC(50)=1.37microM) in HBL-100 (breast) cell line while compounds 17 (IC(50)=3.7microM) and 22 (IC(50)=3.0microM) have shown high cytotoxicity in KB (oral) and SW-620 (colon) cell lines, respectively. The synthesized 1,8-naphthyridine-3-carboxamides were also evaluated for anti-inflammatory and myeloprotective activities, indicated by modulation in cytokine and chemokine levels secreted by dendritic cells.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor / methods
  • Humans
  • Inflammation Mediators / antagonists & inhibitors
  • Inflammation Mediators / pharmacology*
  • K562 Cells
  • KB Cells
  • Mice
  • NIH 3T3 Cells
  • Naphthyridines / chemical synthesis*
  • Naphthyridines / pharmacology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents
  • Inflammation Mediators
  • Naphthyridines