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Curr Opin Struct Biol. 2007 Oct;17(5):513-20. Epub 2007 Oct 22.

Functions of cell surface galectin-glycoprotein lattices.

Author information

1
Laboratorio de InmunopatologĂ­a, Instituto de BiologĂ­a y Medicina Experimental IBYME, CONICET, Buenos Aires, Argentina. gabyrabi@ciudad.com.ar

Abstract

Programmed remodeling of cell surface glycans by the sequential action of specific glycosyltransferases can control biological processes by generating or masking ligands for endogenous lectins. Galectins, a family of animal lectins with affinity for beta-galactosides, can form multivalent complexes with cell surface glycoconjugates and deliver a variety of intracellular signals to modulate cell activation, differentiation, and survival. Recent efforts involving genetic or biochemical manipulation of O-glycosylation and N-glycosylation pathways, as well as blockade of the synthesis of endogenous galectins, have illuminated essential roles for galectin-glycoprotein lattices in the control of biological processes including receptor turnover and endocytosis, host-pathogen interactions, and immune cell activation and homeostasis.

PMID:
17950594
PMCID:
PMC2100406
DOI:
10.1016/j.sbi.2007.09.002
[Indexed for MEDLINE]
Free PMC Article

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