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Curr Opin Neurobiol. 2007 Oct;17(5):516-24. Epub 2007 Oct 22.

Structural plasticity of axon terminals in the adult.

Author information

1
Friedrich Miescher Institut, Maulbeerstrasse 66, CH-4058 Basel, Switzerland. nadine.gogolla@fmi.ch

Abstract

There is now conclusive evidence for widespread ongoing structural plasticity of presynaptic boutons and axon side-branches in the adult brain. The plasticity complements that of postsynaptic spines, but axonal plasticity samples larger volumes of neuropil, and has a larger impact on circuit remodeling. Axons from distinct neurons exhibit unique ratios of stable (t1/2>9 months) and dynamic (t1/2 5-20 days) boutons, which persist as spatially intermingled subgroups along terminal arbors. In addition, phases of side-branch dynamics mediate larger scale remodeling guided by synaptogenesis. The plasticity is most pronounced during critical periods; its patterns and outcome are controlled by Hebbian mechanisms and intrinsic neuronal factors. Novel experience, skill learning, life-style, and age can persistently modify local circuit structure through axonal structural plasticity.

PMID:
17950593
DOI:
10.1016/j.conb.2007.09.002
[Indexed for MEDLINE]
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