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Trends Pharmacol Sci. 2007 Nov;28(11):551-5. Epub 2007 Oct 22.

Neuronal Gq/11-coupled dopamine receptors: an uncharted role for dopamine.

Author information

1
Department of Pharmacology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

Abstract

There is strong evidence for the existence of Gq/11-coupled dopamine receptors in the brain but the mechanism by which dopamine signaling activates Gq/11, or its roles in neuronal function, are only just beginning to be understood. The importance of such a pathway is underlined by putative links between dopamine-regulated phosphoinositide signaling and several central nervous system disorders that include schizophrenia, addiction and Parkinson's disease.

PMID:
17950471
DOI:
10.1016/j.tips.2007.10.001
[Indexed for MEDLINE]

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