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J Biomed Mater Res. 1991 Dec;25(12):1431-42.

In vivo biocompatibility of an aliphatic crosslinked polyurethane in rabbit.

Author information

1
Division for Technical Evaluation of Biomaterials, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.

Abstract

A cage implantation technique has been adopted in a rabbit animal model to investigate the biocompatibility of an aliphatic crosslinked polyurethane based on hexamethylene diisocyanate (HDI). In this study, four cages are represented; the cage containing the candidate polyurethane material, biomedical grade polyurethane (Tecoflex), the commercial grade polyvinylchloride (PVC), and an empty cage which were implanted subcutaneously in rabbits. Exudates were aspirated from these cages at 4, 7, 14, and 21 days postimplantation. Exudates were analyzed for variations in proteins, cell counts, and extracellular enzymes. Results with the four types of cage implants showed that the candidate polyurethane caused an inflammatory response comparable to that caused by medical-grade Tecoflex and the empty cage control.

PMID:
1794993
DOI:
10.1002/jbm.820251203
[Indexed for MEDLINE]

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