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Org Lett. 2007 Nov 8;9(23):4713-6. Epub 2007 Oct 19.

Asymmetric CuH-catalyzed hydrosilylations en route to the C-9 epimer of amphidinoketide iota.

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1
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106, USA. lipshutz@chem.ucsb.edu

Abstract

The C-9 diastereomer of amphidinoketide I has been synthesized. An asymmetric CuH-catalyzed hydrosilylation based on the Solvias nonracemic Josiphos-related ligand (R,S)-PPF-P(t-Bu)2 was successfully used to introduce each of three stereocenters found in the target compound.

PMID:
17949006
DOI:
10.1021/ol701999h
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