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Non-viral charge reversal vectors for pDNA delivery.

Author information

1
Dept. of Biomed. Eng., Boston Univ., MA 02215, USA. cprata@bu.edu

Abstract

A synthetic vector that transform from a cationic to an anionic lipid intracellularly is described. This charge-reversal lipid was synthesized and characterized, including the supramolecular complex it forms with DNA. Enhanced gene transfection was observed using this synthetic vector compared to current cationic lipids.

PMID:
17946624
DOI:
10.1109/IEMBS.2006.260181
[Indexed for MEDLINE]

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