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A serial dilution microfluidic device for cytotoxicity assays.

Author information

1
Dept. of Biomed. Eng., North Carolina Univ., Chapel Hill, NC, USA. atoneill@ncsu.edu

Abstract

A novel microfluidic device is presented which creates a linear serial dilution of two input fluid streams. This platform facilitates higher productivity as a component of a high throughput cytotoxicity testing strategy. A modeling solution is presented to create custom linear dilution schemes. The featured device creates a serial dilution of two solutions in the range of 1:9 through 9:1 across nine discrete dilutions. It has been validated to create a highly linear progression of dilutions with an R2 value of 0.9993. The device functions equivalently over a wide range of flow rates. The standard deviation of dilution values averages 0.76% over six flow rates spanning 0.5 to 16 microl min(-1).

PMID:
17946141
DOI:
10.1109/IEMBS.2006.259270
[Indexed for MEDLINE]
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