Format

Send to

Choose Destination
See comment in PubMed Commons below

Integrated semiconductor optical sensors for chronic, minimally-invasive imaging of brain function.

Author information

1
Department of Electrical Engineering, Stanford University, Stanford, CA, USA. leet@stanford.edu

Abstract

Intrinsic optical signal (IOS) imaging is a widely accepted technique for imaging brain activity. We propose an integrated device consisting of interleaved arrays of gallium arsenide (GaAs) based semiconductor light sources and detectors operating at telecommunications wavelengths in the near-infrared. Such a device will allow for long-term, minimally invasive monitoring of neural activity in freely behaving subjects, and will enable the use of structured illumination patterns to improve system performance. In this work we describe the proposed system and show that near-infrared IOS imaging at wavelengths compatible with semiconductor devices can produce physiologically significant images in mice, even through skull.

PMID:
17946016
PMCID:
PMC2562279
DOI:
10.1109/IEMBS.2006.260041
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for IEEE Engineering in Medicine and Biology Society Icon for PubMed Central
    Loading ...
    Support Center