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Biol Psychiatry. 2008 Mar 15;63(6):557-62. Epub 2007 Oct 22.

Neuronal correlates of obsessions in the caudate nucleus.

Author information

1
Department of Clinical Neurophysiology, CHU de Bordeaux, Place Amélie Rabat-Léon, Centre National de Recherche Scientifique Unité Mixte de Recherche 5543, Université Victor Segalen, Bordeaux, France.

Abstract

BACKGROUND:

Metabolic overactivity of corticosubcortical loops including the caudate nucleus (CN) has been reported in obsessive-compulsive disorder (OCD) using functional imaging techniques. However, direct proof of a modification of neuronal activity within the CN of OCD patients is still lacking. We tested the hypothesis that obsessions or compulsions might be associated with particular features of neuronal activity in the CN of OCD patients.

METHODS:

Single unit recordings were performed peroperatively in the CN of three patients with severe forms of obsessive-compulsive disorder (OCD) who were candidates for deep brain stimulation of the CN. Severity of obsessions was assessed preoperatively with the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and peroperatively with a subjective obsession score based on a visual analog scale (VAS).

RESULTS:

Frequency of CN discharge and variability of interspike intervals were found to be abnormally high in two patients with a high VAS score during surgery but not in one with a low VAS score. Lateralization and depth of recording influenced neuronal activity variably among patients.

CONCLUSIONS:

Because the three patients had high Y-BOCS scores before surgery, these findings suggest that caudate hyperactivity in OCD is concomitant with the occurrence of the obsession process.

PMID:
17945196
DOI:
10.1016/j.biopsych.2007.06.023
[Indexed for MEDLINE]

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