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Eur J Pharmacol. 1991 Aug 16;201(1):117-20.

N-methyl-D-aspartate increases the excitability of nigrostriatal dopamine terminals.

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1
Department of Psychology, University of Reading, Berkshire, U.K.

Abstract

The terminal excitability of nigrostriatal dopamine cells was measured before and after i.v. administration of N-methyl-D-aspartate (NMDA; 1 or 4 mg/kg), the competitive NMDA antagonist AP-7 (2-amino-7-phosphonoheptanoic acid) (4 mg/kg) or saline. NMDA produced a dose-dependent increase in terminal excitability, in the absence of an effect on the somal membrane, whereas AP-7 and saline were without effect. These data provide convergent in vivo evidence that glutamate can enhance striatal dopamine release via the NMDA receptor.

PMID:
1794413
DOI:
10.1016/0014-2999(91)90332-k
[Indexed for MEDLINE]

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