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J Pharm Sci. 2008 Aug;97(8):2855-77.

Engineering of pharmaceutical materials: an industrial perspective.

Author information

1
Pharmaceutical Development Services, Patheon, Inc., 2100 Syntex Court, Mississauga, Ontario, Canada L5N 7K9. kwok.chow@patheon.com

Abstract

Crystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as co-processing technologies being applied in the pharmaceutical industry are also presented together with selected examples of crystal form design, crystal form selection and crystal modifications for illustration purposes.

PMID:
17943933
DOI:
10.1002/jps.21212
[Indexed for MEDLINE]
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