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Org Biomol Chem. 2007 Nov 7;5(21):3399-406. Epub 2007 Sep 21.

Engineering proteins with tailored nanomechanical properties: a single molecule approach.

Author information

1
The University of British Columbia, Department of Chemistry, 2036 Main Mall, Vancouver, Canada. hongbin@chem.ubc.ca

Abstract

Elastomeric proteins underlie the elasticity of natural adhesives, cell adhesion and muscle proteins. They also serve as structural materials with superb mechanical properties. Single molecule force spectroscopy has made it possible to directly probe the mechanical properties of elastomeric proteins at the single molecule level and revealed insights into the molecular design principles of elastomeric proteins. Combining single molecule atomic force microscopy and protein engineering techniques, it has become possible to engineer proteins with tailored nanomechanical properties. These efforts are paving the way to design artificial elastomeric proteins with well-defined nanomechanical properties for application in nanomechanics and materials sciences.

PMID:
17943196
DOI:
10.1039/b710321m
[Indexed for MEDLINE]

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