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Nat Rev Genet. 2007 Nov;8(11):857-68.

Recent and ongoing selection in the human genome.

Author information

  • 1Center for Comparative Genomics, University of Copenhagen, Universitetsparken 15, 2100 Kbh Ø, Denmark. rasmus@binf.ku.dk

Abstract

The recent availability of genome-scale genotyping data has led to the identification of regions of the human genome that seem to have been targeted by selection. These findings have increased our understanding of the evolutionary forces that affect the human genome, have augmented our knowledge of gene function and promise to increase our understanding of the genetic basis of disease. However, inferences of selection are challenged by several confounding factors, especially the complex demographic history of human populations, and concordance between studies is variable. Although such studies will always be associated with some uncertainty, steps can be taken to minimize the effects of confounding factors and improve our interpretation of their findings.

PMID:
17943193
PMCID:
PMC2933187
DOI:
10.1038/nrg2187
[PubMed - indexed for MEDLINE]
Free PMC Article
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