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Nat Rev Cancer. 2007 Nov;7(11):861-9.

The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.

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Darmstadt University of Technology, Radiation Biology and DNA Repair, 64287 Darmstadt, Germany.


DNA damage responses (DDR) encompass DNA repair and signal transduction pathways that effect cell cycle checkpoint arrest and/or apoptosis. How DDR pathways respond to low levels of DNA damage, including low doses of ionizing radiation, is crucial for assessing environmental cancer risk. It has been assumed that damage-induced cell cycle checkpoints respond to a single double strand break (DSB) but the G2/M checkpoint, which prevents entry into mitosis, has recently been shown to have a defined threshold of 10-20 DSBs. Here, we consider the impact of a negligent G2/M checkpoint on genomic stability and cancer risk.

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