Format

Send to

Choose Destination
See comment in PubMed Commons below
Mult Scler. 2008 Jan;14(1):81-5. Epub 2007 Oct 17.

Retrospective comparison of the original and revised McDonald criteria in a general neurology practice in Ireland.

Author information

  • 1Department of Neurology, AMNCH, Tallaght, Dublin 24, Ireland. drjohnmchugh@ireland.com

Abstract

BACKGROUND:

The McDonald criteria were introduced in 2001 as guidelines to facilitate early and accurate diagnosis of multiple sclerosis (MS). They were revised in 2005. Although validated in a number of research-focused clinical centres, their adequacy and utility in the general neurology setting is less certain.

OBJECTIVE:

In this study, we assessed new diagnoses of MS in our practice for compliance with both the original and the revised criteria.

METHODS:

We retrospectively identified new diagnoses of MS from 2001. Clinical notes and imaging were evaluated for compliance with McDonald criteria.

RESULTS:

Sixty-two patients were included: 53 with ;practice-definite' and nine with ;practice-possible' diagnoses of MS. At the time of diagnosis, 47% of the ;practice-definite' group fulfilled the 2001 criteria and 49% the revised criteria. Among patients not satisfying the criteria at time of diagnosis, 21% went on to fulfil the McDonald criteria over the 23-month follow-up.

CONCLUSIONS:

There is a considerable gap between the clinical diagnosis of MS in a general neurology setting and compliance with the McDonald criteria. Failure to perform follow-up MRI on patients with clinically isolated syndromes is a sizeable factor in this diagnostic-gap and needs to be improved. In this setting, practical differences between the original and revised criteria appear to be small.

PMID:
17942523
DOI:
10.1177/1352458507081169
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center