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Curr Opin Cell Biol. 2007 Oct;19(5):578-83. Epub 2007 Oct 17.

Extracellular matrix: from atomic resolution to ultrastructure.

Author information

1
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

Abstract

The extracellular matrix (ECM) is a highly organized multimolecular structure, essential for life in higher organisms. Although substantial high-resolution structural information is available for relatively small fragments of ECM components, the inherent difficulty in preparing and analyzing samples of large, fibrous polymers impedes structural efforts. Here, we review recent advances in understanding the structure of three important ECM components: collagen, fibrillin and fibronectin. Emphasis is placed on the key role of intermolecular interactions in assembling larger, microm scale, structures.

PMID:
17942296
PMCID:
PMC4827755
DOI:
10.1016/j.ceb.2007.09.005
[Indexed for MEDLINE]
Free PMC Article

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