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Pediatr Nephrol. 2008 Apr;23(4):507-25. Epub 2007 Oct 17.

Diabetic nephropathy in children and adolescents.

Author information

1
The Institute of Mother and Child Healthcare of Serbia Dr Vukan Cupic, Belgrade, Serbia. maloun@eunet.yu

Abstract

Type 1 diabetes mellitus (T1DM) commonly occurs in childhood or adolescence, although the rising prevalence of type 2 diabetes mellitus (T2DM) in these age groups is now being seen worldwide. Diabetic nephropathy (DN) develops in 15-20% of subjects with T1DM and in similar or higher percentage of T2DM patients, causing increased morbidity and premature mortality. Although overt DN or kidney failure caused by either type of diabetes are very uncommon during childhood or adolescence, diabetic kidney disease in susceptible patients almost certainly begins soon after disease onset and may accelerate during adolescence, leading to microalbuminuria or incipient DN. Therefore, all diabetics warrant ongoing assessment of kidney function and screening for the earliest manifestations of renal injury. Pediatric health care professionals ought to understand about risk factors, strategy for prevention, method for screening, and treatment of early DN. This review considers each form of diabetes separately, including natural history, risk factors for development, screening for early manifestations, and strategy recommended for prevention and treatment of DN in children and adolescents.

PMID:
17940807
DOI:
10.1007/s00467-007-0583-2
[Indexed for MEDLINE]

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