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Yale J Biol Med. 2006 Dec;79(3-4):169-72.

Efficacy of low dose clofarabine in refractory precursor T- acute lymphoblastic leukemia.

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Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.


Refractory T-lymphoblastic leukemia in adults has a poor prognosis in patients who relapse after allogeneic stem cell transplantation, and relatively few new agents have demonstrated activity. Clofarabine is a novel nucleoside analog that has been associated with significant clinical activity in relapsed pediatric B-ALL. We used low dose clofarabine and induced a remission in a patient who relapsed in the skin and marrow after allogeneic transplant and was refractory to nelarabine and report a near complete response, suggesting significant activity for low intermittent dose clofarabine in patients with relapsed T-cell leukemias.

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