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Bioorg Med Chem Lett. 2007 Dec 1;17(23):6467-71. Epub 2007 Oct 4.

2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2.

Author information

1
Johnson & Johnson Pharmaceutical Research & Development, L.L.C, 3210 Merryfield Row, San Diego, CA 92121, USA. dneff1@prdus.jnj.com

Abstract

A series of benzimidazole compounds containing pendant alcohol and amine moieties was found to be active against checkpoint kinase Chk2. These compounds were prepared to examine a potential hydrogen bond interaction with an active site residue and to investigate replacement of a biaryl linker with an aliphatic system in an effort to improve solubility.

PMID:
17937984
DOI:
10.1016/j.bmcl.2007.09.098
[Indexed for MEDLINE]

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