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Am J Med Genet A. 2007 Dec 15;143A(24):3038-46.

Multifocal rapidly involuting congenital hemangioma: a link to chorangioma.

Author information

1
Department of Plastic Surgery, Vascular Anomalies Center, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. john.mulliken@childrens.harvard.edu

Abstract

Common infantile hemangioma is intriguing because of its variable presentation, rapid postnatal growth and slow regression in childhood. Interest in this tumor has increased with the recognition that it can be associated with structural anomalies in the craniofacial and ventral-caudal regions. The phenotype has expanded by characterization of rare vascular tumors that arise in the fetus and manifest at birth as rapidly involuting congenital hemangioma (RICH) or non-involuting congenital hemangioma (NICH). We describe a boy born with three RICH on the abdominal wall; one extended into the base of the umbilical cord. Two weeks later a small, infantile hemangioma arose on his neck. This patient stimulated a review of what is known about placental vascular tumors and their possible relationship to fetal and infantile hemangiomas. We suggest that chorangioma and umbilical cord hemangioma are clinically and histopathologically similar to cutaneous and hepatic RICH. These placental vascular tumors can also occur in conjunction with solitary and multiple infantile hemangiomas.

PMID:
17937433
DOI:
10.1002/ajmg.a.31964
[Indexed for MEDLINE]

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