Format

Send to

Choose Destination
Pharmacol Res. 2007 Nov;56(5):393-405. Epub 2007 Sep 8.

Endocannabinoid system involvement in brain reward processes related to drug abuse.

Author information

1
Institut de Physiologie et Biologie Cellulaires, University of Poitiers, Centre National de la Recherche Scientifique UMR 6187, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France. marcello.solinas@univ-poitiers.fr

Abstract

Cannabis is the most commonly abused illegal drug in the world and its main psychoactive ingredient, delta-9-tetrahydrocannabinol (THC), produces rewarding effects in humans and non-human primates. Over the last several decades, an endogenous system comprised of cannabinoid receptors, endogenous ligands for these receptors and enzymes responsible for the synthesis and degradation of these endogenous cannabinoid ligands has been discovered and partly characterized. Experimental findings strongly suggest a major involvement of the endocannabinoid system in general brain reward functions and drug abuse. First, natural and synthetic cannabinoids and endocannabinoids can produce rewarding effects in humans and laboratory animals. Second, activation or blockade of the endogenous cannabinoid system has been shown to modulate the rewarding effects of non-cannabinoid psychoactive drugs. Third, most abused drugs alter brain levels of endocannabinoids in the brain. In addition to reward functions, the endocannabinoid cannabinoid system appears to be involved in the ability of drugs and drug-related cues to reinstate drug-seeking behavior in animal models of relapse. Altogether, evidence points to the endocannadinoid system as a promising target for the development of medications for the treatment of drug abuse.

PMID:
17936009
PMCID:
PMC2189556
DOI:
10.1016/j.phrs.2007.09.005
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center