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Diabetes Res Clin Pract. 2008 Feb;79(2):214-9. Epub 2007 Nov 1.

Expression of TNF-alpha protein in omental and subcutaneous adipose tissue in obesity.

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1
Department of Endocrinology, First Affiliated Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, Liaoning 110001, China.

Abstract

BACKGROUND:

During the last several years the role of adipose tissue in contributing to obesity-associated cardiovascular and metabolic risk has gained much attention.

AIM:

To examine the expression of TNF-alpha protein in omental and subcutaneous adipose tissue in correlation with plasma PAI-1 and other clinical parameters in obesity subjects.

MATERIAL AND METHODS:

Paired biopsies of omental and subcutaneous fat were collected during surgery in 32 obesity subjects. The expression of TNF-alpha protein in omental and subcutaneous fat was quantified by using Western blot method, and correlations with plasma PAI-1, homeostasis model assessment insulin resistance (HOMA-IR) and lipid were investigated.

RESULTS:

TNF-alpha protein expression was higher in omental than in subcutaneous adipose tissue (P<0.01). Significant positive linear correlations were found between TNF-alpha protein in omental adipose tissue and plasma PAI-1 in obesity subjects. TNF-alpha protein in omental fat was positively associated with HOMA-IR, triglycerides and negatively with HDL-cholesterol.

CONCLUSION:

TNF-alpha expression in omental adipose tissue could play a key role in contributing to cardiovascular risk in central obesity subjects.

PMID:
17935818
DOI:
10.1016/j.diabres.2007.08.030
[Indexed for MEDLINE]
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