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Dig Dis Sci. 2008 Apr;53(4):977-81. Epub 2007 Oct 13.

Sarcoidosis in patients with celiac disease.

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1
Department of Medicine, Columbia University Medical Center, 180 Fort Washington Avenue, Room 956, New York, NY 10032, USA.

Abstract

PURPOSE:

Several case reports and European studies have suggested an association between sarcoidosis and celiac disease; however, they have been inconsistent. We therefore analyzed a large cohort of celiac-disease patients to assess this association.

METHODS:

An anonymized database of patients with celiac disease was reviewed to determine the number of patients with sarcoidosis. Age- and gender-adjusted standardized morbidity ratios with corresponding 95% confidence intervals (CI) were calculated by comparing results to US-population-derived prevalence data.

RESULTS:

Ten patients were found to have a comorbid diagnosis of sarcoidosis, representing an age- and gender-adjusted standardized morbidity ratio of 36.8 (95% CI 26.7-50.9).

CONCLUSIONS:

In this cohort of patients with celiac disease, there was a significantly increased risk of sarcoidosis when compared with the American white population. This further strengthens prior associations that have been made suggesting a shared mechanism behind the etiologies of celiac disease and sarcoidosis.

PMID:
17934825
DOI:
10.1007/s10620-007-9974-2
[Indexed for MEDLINE]
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