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J Bacteriol. 2007 Dec;189(24):9140-4. Epub 2007 Oct 12.

YhbO protects cells against multiple stresses.

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1
Stress Molecules, Institut Jacques Monod, Université Paris 7, 2 Place Jussieu, 75005 Paris, France.

Abstract

YhbO is a member of the DJ-1/ThiJ/Pfp1 superfamily, which includes chaperones, peptidases, and the Parkinson's disease protein DJ-1. A yhbO-disrupted mutant of Escherichia coli is highly sensitive to oxidative, thermal, UV, and pH stresses, and the putative nucleophilic cysteine C104 of YhbO is required for stress resistance. These results suggest that YhbO affects a central process in stress management.

PMID:
17933887
PMCID:
PMC2168597
DOI:
10.1128/JB.01208-07
[Indexed for MEDLINE]
Free PMC Article
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