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Pediatr Dev Pathol. 2007 Sep-Oct;10(5):409-15.

Malignant rhabdoid tumor mimicking hepatoblastoma: a case report and literature review.

Author information

1
Division of Hematology/Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. lars.wagner@cchmc.org

Abstract

Hepatoblastoma accounts for the vast majority of malignant primary liver tumors in infancy. In contrast, rhabdoid tumors arising in the liver are extremely rare, but they can share clinical and histologic features with hepatoblastoma and can create diagnostic confusion, especially when one is dealing with small biopsies. In this case report we demonstrate that immunohistochemical and molecular techniques can identify the characteristic loss of INI1 and facilitate making the correct diagnosis of primary hepatic malignant rhabdoid tumor. Important similarities and differences between hepatoblastoma and rhabdoid tumors are reviewed, and suggestions are offered to help distinguish these 2 tumor types.

PMID:
17929989
DOI:
10.2350/06-08-0155.1
[Indexed for MEDLINE]

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