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J Surg Oncol. 2008 Jan 1;97(1):51-6.

Prognostic significance of cyclooxygenase-2 expression and nuclear p53 accumulation in patients with colorectal cancer.

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1
Research Center for Resistant Cells, Chosun University College of Medicine, Gwangju, Korea.

Abstract

BACKGROUND:

Cyclooxygenase (COX)-2 is believed to be an important enzyme related to the pathogenesis of colorectal cancer (CRC). p53 has been reported to be a negative regulator of COX-2 expression in in vitro studies. The aim of this study was to investigate COX-2 expression and its relationship with nuclear p53 accumulation and their prognostic significance in CRC.

METHODS:

COX-2 expression and nuclear p53 accumulation were examined by immunohistochemistry in 231 sporadic CRCs. Their prognostic significance and interrelationship were statistically evaluated.

RESULTS:

We found 42.4% of the 231 cases of CRCs with positive COX-2 expression. Nuclear p53 accumulation was observed in 46.8% of cases. There was no significant correlation between COX-2 expression and nuclear p53 accumulation. COX-2 expression had no correlation with patient survival, whereas nuclear p53 accumulation was significantly correlated with poor patient survival on univariate and multivariate analysis.

CONCLUSIONS:

These results suggest that COX-2 expression does not play a role in the prognosis of CRC and COX-2 expression is not affected by the status of nuclear p53 accumulation in CRC. In addition, our findings support that nuclear p53 accumulation may be a useful prognostic marker for patients with CRC.

PMID:
17929263
DOI:
10.1002/jso.20907
[Indexed for MEDLINE]
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