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J Invest Dermatol. 2008 Mar;128(3):606-15. Epub 2007 Oct 11.

Cellular genomic maps help dissect pathology in human skin disease.

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1
Laboratory of Investigative Dermatology, The Rockefeller University, New York, New York 10021-6399, USA.

Abstract

Genomic signature maps of different cell types can aid in the interpretation of genomic data of specimens collected during disease states. We have defined "lineage-specific" genes, as well as "activation" genes, for cellular components of the skin: keratinocytes, fibroblasts, macrophages, monocytes, T cells, immature, and mature dendritic cells (DCs). Re-analysis of a previously published gene set of psoriasis then provided a model for assessing the usefulness of these maps. We were able to ascribe over 90% of these genes to specific cell types, and there was a surprisingly large contribution from DCs. This shows the utility of such cellular gene maps.

PMID:
17928892
DOI:
10.1038/sj.jid.5701067
[Indexed for MEDLINE]
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