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JAMA. 2007 Oct 10;298(14):1652-60.

Job strain and risk of acute recurrent coronary heart disease events.

Author information

1
Unité de Recherché en Santé des Populations, Université Laval, Québec, Canada.

Abstract

CONTEXT:

There is evidence that job strain increases the risk of a first coronary heart disease (CHD) event. However, little is known about its association with the risk of recurrent CHD events after a first myocardial infarction (MI).

OBJECTIVE:

To determine whether job strain increases the risk of recurrent CHD events.

DESIGN, SETTING, AND PATIENTS:

Prospective cohort study of 972 men and women aged 35 to 59 years who returned to work after a first MI and were then followed up between February 10, 1996, and June 22, 2005. Patients were interviewed at baseline (on average, 6 weeks after their return to work), then after 2 and 6 years subsequently. Job strain, a combination of high psychological demands and low decision latitude, was evaluated in 4 quadrants: high strain (high demands and low latitude), active (high demands and high latitude), passive (low demands and low latitude), and low strain. A chronic job strain variable was constructed based on the first 2 interviews, and patients were divided into those exposed to high strain at both interviews and those unexposed to high strain at 1 or both interviews. The survival analyses were presented separately for 2 periods: before 2.2 years and at 2.2 years and beyond.

MAIN OUTCOME MEASURE:

The outcome was a composite of fatal CHD, nonfatal MI, and unstable angina.

RESULTS:

The outcome was documented in 206 patients. In the unadjusted analysis, chronic job strain was associated with recurrent CHD in the second period after 2.2 years of follow-up (hazard ratio [HR], 2.20; 95% CI, 1.32-3.66; respective event rates for patients exposed and unexposed to chronic job strain, 6.18 and 2.81 per 100 person-years). Chronic job strain remained an independent predictor of recurrent CHD in a multivariate model adjusted for 26 potentially confounding factors (HR, 2.00; 95% CI, 1.08-3.72).

CONCLUSION:

Chronic job strain after a first MI was associated with an increased risk of recurrent CHD.

PMID:
17925517
DOI:
10.1001/jama.298.14.1652
[Indexed for MEDLINE]

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