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Clin Toxicol (Phila). 2008 Mar;46(3):270-3.

Metabolic acidosis in prometryn (triazine herbicide) self-poisoning.

Author information

1
Poison Control Centre, University Medical Centre Ljubljana, Ljubljana, Slovenia. miran.brvar@kclj.si

Abstract

INTRODUCTION:

Prometryn is a triazine herbicide, which is one of the most extensively used groups of herbicides. The mechanism of acute triazine herbicide toxicity in humans is not known. We report a first case of acute prometryn poisoning.

CASE REPORT:

A 62-year-old male ingested 50 g of prometryn and ethanol in a suicide attempt. On arrival two hours after ingestion, he was somnolent and vomited. Seven hours after ingestion laboratory tests showed metabolic acidosis with a calculated anion gap of 47.5 mmol/L and lactate of 23.4 mmol/L. Gas chromatography/mass spectrometry revealed serum prometryn concentrations of 48.1 mg/L. Hemodialysis corrected metabolic acidosis, but the serum prometryn concentration increased to 67.7 mg/L. The lactate level after hemodialysis was 11.7 mmol/L and returned within normal limits 47 hours after ingestion. The patient was discharged without any sequelae after psychiatric evaluation.

CONCLUSION:

In high anion gap metabolic acidosis we should consider poisoning with prometryn and other triazine herbicides. Hemodialysis corrects metabolic derangements, but it does not lower serum prometryn concentration.

PMID:
17924252
DOI:
10.1080/15563650701665126
[Indexed for MEDLINE]

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