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Arch Ophthalmol. 2007 Oct;125(10):1396-401.

C-reactive protein level and risk of aging macula disorder: The Rotterdam Study.

Author information

1
Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

Abstract

OBJECTIVE:

To examine whether C-reactive protein (CRP) level is a risk factor for aging macula disorder (AMD) in a general population.

METHODS:

We examined serum high-sensitivity CRP (HsCRP) levels in 4914 participants of the population-based Rotterdam Study at risk for AMD. After a mean follow-up of 7.7 years, 561 cases of early and 97 cases of late incident AMD (iAMD) were identified. We used Cox proportional hazards regression models to estimate hazard ratios and corresponding 95% confidence intervals (CIs).

RESULTS:

After adjustment for age and sex, hazard ratios were 1.11 (95% CI, 1.02-1.21) per standard deviation increase in HsCRP level for early iAMD and 1.28 (95% CI, 1.02-1.60) for late iAMD. Hazard ratios for early iAMD increased per quartile increase in HsCRP level as follows: second quartile, 1.19 (95% CI, 0.94-1.52); third quartile, 1.29 (95% CI, 1.01-1.64); and fourth quartile, 1.33 (95% CI, 1.05-1.70). The risk of late iAMD was higher in all upper quartiles of HsCRP.

CONCLUSION:

Elevated baseline levels of HsCRP were associated with the development of early and late AMD in this large population-based cohort.

PMID:
17923549
DOI:
10.1001/archopht.125.10.1396
[Indexed for MEDLINE]

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