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Bioorg Med Chem Lett. 2007 Dec 1;17(23):6633-7. Epub 2007 Sep 15.

New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation.

Author information

1
Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. mfrohn@amgen.com

Abstract

We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro.

PMID:
17920884
DOI:
10.1016/j.bmcl.2007.09.043
[Indexed for MEDLINE]

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