New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation

Bioorg Med Chem Lett. 2007 Dec 1;17(23):6633-7. doi: 10.1016/j.bmcl.2007.09.043. Epub 2007 Sep 15.

Abstract

We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Benzimidazoles / agonists
  • Benzimidazoles / chemical synthesis
  • Benzimidazoles / pharmacology
  • CHO Cells
  • Cell Migration Inhibition
  • Chemotaxis, Leukocyte / physiology
  • Cricetinae
  • Cricetulus
  • Humans
  • Inflammation Mediators / agonists
  • Inflammation Mediators / physiology*
  • Interleukin-6 / metabolism
  • Molecular Probes / analysis*
  • Molecular Probes / chemical synthesis*
  • Neutrophils / cytology
  • Neutrophils / drug effects
  • Neutrophils / metabolism
  • Receptors, Formyl Peptide / agonists
  • Receptors, Formyl Peptide / blood
  • Receptors, Formyl Peptide / physiology*
  • Receptors, Lipoxin / agonists
  • Receptors, Lipoxin / blood
  • Receptors, Lipoxin / physiology*

Substances

  • Benzimidazoles
  • FPR2 protein, human
  • Inflammation Mediators
  • Interleukin-6
  • Molecular Probes
  • Receptors, Formyl Peptide
  • Receptors, Lipoxin
  • benzimidazolone