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Anal Chim Acta. 2007 Oct 10;601(2):141-55. Epub 2007 Sep 1.

Optical sensing systems for microfluidic devices: a review.

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Chemo & Biosensors Group, School of Pharmacy, University of Jember, Jember 68121, Indonesia.


This review deals with the application of optical sensing systems for microfluidic devices. In the "off-chip approach" macro-scale optical infrastructure is coupled, while the "on-chip approach" comprises the integration of micro-optical functions into microfluidic devices. The current progress of the use of both optical sensing approaches in microfluidic devices, as well as its applications is described. In all cases, sensor size and shape profoundly affect the detection limits, due to analyte transport limitation, not to signal transduction limitation. The micro- or nanoscale sensors are limited to picomolar-order detection for practical time scales. The review concludes with an assessment of future directions of optical sensing systems for integrated microfluidic devices.

[Indexed for MEDLINE]

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