Send to

Choose Destination
Trends Microbiol. 2007 Oct;15(10):469-75. Epub 2007 Oct 24.

Microtiter plates as mini-bioreactors: miniaturization of fermentation methods.

Author information

Enzyscreen, Biopartner Center Leiden, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands.


In the past decade, the use of microtiter plates for microbial growth has become widespread, particularly in industry. In parallel, research in academia has provided a thorough insight into the complex relation between well dimensions, culture volumes, orbital shaking conditions and surface tension on the one hand, and oxygen-transfer rates and degrees of mixing on the other. In this review, I will discuss these fundamental issues and describe the current applications of microtiter plates in microbiology. Microtiter plates can now be considered a mature alternative to Erlenmeyer shake flasks.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center