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Neuron. 2007 Oct 4;56(1):33-42.

Perisomatic inhibition.

Author information

1
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary. Freund@koki.hu

Abstract

Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition in the cerebral cortex: the parvalbumin- and cholecystokinin-containing basket cells that are specialized to control rhythm (as a clockwork) and "mood" (as a fine-tuning device), respectively, of network oscillations. Pathology extends this conclusion further, as the former is implicated in epilepsy and the latter in anxiety. The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex.

PMID:
17920013
DOI:
10.1016/j.neuron.2007.09.012
[Indexed for MEDLINE]
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