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Neurosci Lett. 1991 Nov 25;133(1):36-40.

A human phase-response curve to light.

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  • 1Department of Physiological Sciences, University of Manchester, U.K.


Using 'classical' experimental protocols, a human phase-response curve (PRC) to a single 3-h bright light pulse has been established. When the light pulse was centred slightly before the time of body temperature minimum, the circadian system delayed, whilst a pulse slightly after the minimum advanced it. Maximum phase shifts were about 2 h. When light pulses over 3 successive cycles were used, larger shifts (4-7 h) were produced. It is concluded that the human PRC does not differ in principle from that found in other species, except with respect to the light intensity required.

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