Format

Send to

Choose Destination
Bioorg Med Chem. 2008 Jan 1;16(1):322-35. Epub 2007 Sep 22.

Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940.

Author information

1
Howard L. Hunter Laboratory, Clemson University, Clemson, SC 29634-0973, USA. huffman@clemson.edu

Abstract

A series of 1-deoxy analogs of CP-47,497 (8 and 13, n=0-7) and 1-deoxy analogs of CP-55,940 (9, n=0-7) have been synthesized and their affinities for the cannabinoid CB(1) and CB(2) receptors have been determined. Although the majority of these compounds exhibit selectivity for the CB(2) receptor, none have greater than modest affinity for either receptor. The interactions of these 1-deoxy nontraditional cannabinoids with the CB(2) receptor are discussed.

PMID:
17919913
PMCID:
PMC2262798
DOI:
10.1016/j.bmc.2007.09.033
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center