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Curr Opin Struct Biol. 2007 Dec;17(6):726-35. Epub 2007 Oct 4.

Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways.

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1
Structural Biology Program, Sloan-Kettering Institute, 1275 York Ave., New York, NY 10065, USA.

Abstract

Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins regulate a diverse array of cellular pathways through post-translational attachment to protein substrates. Ub/Ubl-mediated signaling is initiated through E1, E2, and E3-mediated conjugation, transduced by proteins that recognize Ub/Ubl-modified substrates, and terminated by proteases which remove the Ub/Ubl from the substrate. Recent structural studies have elucidated mechanisms pertinent to Ub/Ubl conjugation, recognition, and deconjugation, highlighting essential steps during Ub/Ubl modification that illustrate common and divergent mechanistic themes within this important process.

PMID:
17919899
PMCID:
PMC2174906
DOI:
10.1016/j.sbi.2007.08.018
[Indexed for MEDLINE]
Free PMC Article
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