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J Antibiot (Tokyo). 2007 Sep;60(9):582-5.

Trierixin, a novel Inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. II. structure elucidation.

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1
Department of Bioscience and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Japan.

Abstract

Trierixin, a new member of the triene-ansamycin group, has been isolated from the fermentation broth of Streptomyces sp. AC654 as an inhibitor of ER stress-induced XBP1 activation. The structure of trierixin was determined on the basis of its spectroscopical and chemical properties. Trierixin possessed a 21-membered macrocyclic lactam, which contains a methylthio-benzenediol structure, and a cyclohexanecarbonylalanine moiety. Trierixin is thus elucidated as 21-thiomethylmycotrienin II.

PMID:
17917242
DOI:
10.1038/ja.2007.74
[Indexed for MEDLINE]
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