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Expert Opin Biol Ther. 2007 Oct;7(10):1575-82.

Natural IgM-mediated innate autoimmunity: a new target for early intervention of ischemia-reperfusion injury.

Author information

1
SUNY-Downstate Medical Center, Department of Anesthesiology, 450 Clarkson Avenue, Brooklyn, NY 11203, USA. ming.zhang@downstate.edu

Abstract

Recent studies showed that innate autoimmunity is an early mechanism for ischemia-reperfusion (I/R) injury. Results from different animal models showed that reperfusion of ischemic tissues elicits an acute inflammatory response involving a complement system, which is activated by autoreactive natural IgM. Moreover, ischemia-specific self-targets were identified. In contrast to the unsuccessful attempts in the past to treat I/R injury, targeting natural IgM-mediated innate autoimmunity may open a new avenue for early intervention.

PMID:
17916049
DOI:
10.1517/14712598.7.10.1575
[Indexed for MEDLINE]

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