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J Environ Sci (China). 2007;19(4):385-6.

Metabolism of benzo[a]pyrene in peroxynitrite/Fe(III) porphyrin system.

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1
College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China. luoyj@bjut.edu.cn

Abstract

The peroxynitrite/porphyrin biomimetic system was established to investigate the effects of peroxynitrite on benzo[a]pyrene (B[a]P) metabolism. Three model systems consisting of different iron porphyrins were compared, and the results showed that the peroxynitrite/T(p-Cl)PPFeCl system was the highest catalytic efficiency in the metabolism of B[a]P. We analyzed the B[a]P metabolites produced from this system by RP-HPLC method and firstly identified the formation of nitrobenzo[a]pyrenes which are the special metabolites of B[a]P induced by peroxynitrite.

PMID:
17915697
[Indexed for MEDLINE]
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