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J Org Chem. 2007 Oct 26;72(22):8376-82. Epub 2007 Oct 3.

Synthesis and spectral properties of cholesterol- and FTY720-containing boron dipyrromethene dyes.

Author information

1
Department of Chemistry and Biochemistry, Queens College of City University of New York, Flushing, New York 11367-1597, USA.

Abstract

Two analogues (1, 2) of free cholesterol and one analogue (3) of the immunosuppressive sphingolipid FTY720 containing a boron dipyrromethene chromophore (BODIPY) were synthesized. The synthetic routes involved preparation of boron dipyrromethene moieties (5, 11), bearing a phenylethynyl group at different positions of the chromophore, and lipids (13, 20) bearing an azido group. The dye was tethered to the lipid via a 1,2,3-triazole in the linker by the click reaction. Analogues derived from 11 [in which an (E)-styrylethynyl moiety is bonded to C-5 of BODIPY] exhibited a marked red shift (approximately 70-80 nm) compared with those derived from 5 (in which a phenylethynyl moiety is bonded to C-8 of BODIPY).

PMID:
17914846
PMCID:
PMC2547128
DOI:
10.1021/jo701475q
[Indexed for MEDLINE]
Free PMC Article

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