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Bioorg Med Chem Lett. 2007 Nov 15;17(22):6066-9. Epub 2007 Sep 25.

Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists.

Author information

1
GlaxoSmithkline, 709 Swedeland Road, King of Prussia, PA 19406, USA. dramane.i.laine@gsk.com

Abstract

In the course of our research program to develop novel muscarinic receptor antagonists for the treatment of COPD, new tropane carbamate derivatives were identified as potent anti-muscarinic agents. The synthesis, structure-activity relationships and pharmacological evaluation that led to the identification of compound 5o, are described.

PMID:
17911022
DOI:
10.1016/j.bmcl.2007.09.071
[Indexed for MEDLINE]

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