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Bioorg Med Chem Lett. 2007 Nov 15;17(22):6096-100. Epub 2007 Sep 15.

Novel scaffold for cathepsin K inhibitors.

Author information

1
Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki, Japan. naoki.teno@novartis.com

Abstract

Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3 optimization and identified highly potent and selective cathepsin K inhibitors 11-20.

PMID:
17911019
DOI:
10.1016/j.bmcl.2007.09.047
[Indexed for MEDLINE]

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