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Acta Cytol. 2007 Sep-Oct;51(5):773-81.

Clinicopathologic significance of eosinophilic pleural effusions in a population with a high prevalence of tuberculosis and cancer.

Author information

1
Kocaeli University, Faculty of Medicine, Department of Pathology, Kocaeli, Turkey. emrecan1999@yahoo.com

Abstract

OBJECTIVE:

To reveal the diagnostic and prognostic significance of eosinophilic pleural effusions (EPEs) and assess their clinical implications.

STUDY DESIGN:

Seventy EPEs from 60 patients among 697 consecutive pleural effusions were investigated from 1996-2005 at Kocaeli University Hospital, Kocaeli, Turkey. Koss and Light's criteria were applied in the analysis, which comprised macroscopic, cytopathologic, biochemical and microbiologic examinations.

RESULTS:

Overall, cancerous underlying conditions were diagnosed in 22 patients (13 malignant and 9 paramalignant), 36.7% of EPEs. Benign causes were found in 43.3% (26 of 60) of the patients. Twelve pleural effusions (20.0%) were idiopathic. The comparison of pleural fluid and peripheral blood findings disclosed no significant difference among the various subgroups.

CONCLUSION:

EPE could be associated with inflammatory, benign, cancerous and paramalignant conditions. A closer search for a definite causes is warranted in the setting of EPEs, especially in populations with a high prevalence of tuberculosis and malignancy, such as in Kocaeli, Turkey, an industrial city in a developing country.

PMID:
17910348
DOI:
10.1159/000325841
[Indexed for MEDLINE]

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