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Doc Ophthalmol. 2008 May;116(3):177-91. Epub 2007 Oct 2.

Retinal safety of a new fluoroquinolone, pradofloxacin, in cats: assessment with electroretinography.

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  • 1Center for Ophthalmology, University of Tübingen, Schleichstrasse 12-16, 72076, Tubingen, Germany. amessias@hotmail.com

Abstract

PURPOSE:

To investigate the safety of a new fluoroquinolone, pradofloxacin, on the cat retina using electroretinogram.

METHODS:

Ganzfeld ERGs were recorded in 40 cats treated orally for 23 days in 4 groups: CTRL (n = 9): placebo-vehicle; PRADO30 (n = 10): pradofloxacin 30 mg/kg/day; PRADO50 (n = 14): pradofloxacin 50 mg/kg/day; and ENRO30 (n = 7): enrofloxacin at toxic doses of 30 mg/kg/day. ERG was performed before treatment and once weekly during the treatment period. An extended ISCEV protocol with addition of 8 steps of increasing luminance in dark adapted condition was carried out to assess: V (max) (saturated scotopic b-wave amplitude) and k (luminance inducing V (max)/2). OCT and retinal histological changes were also investigated.

RESULTS:

Pradofloxacin showed no effects in respect to rod b-wave, V (max), k and maximum scotopic a-wave (P > 0.05). Oscillatory potentials, cone ERG and flicker were also unaltered (P > 0.05). Rod b-wave was undetectable after treatment in ENRO30 group, V (max) was reduced to 10.5% of the baseline (P < 0.05), accompanied by an increase of k by 1 log cd s/m(2) (P < 0.05). Oscillatory potentials, cone b-wave amplitude and 30 Hz flicker amplitude were reduced to 8.3%, 58.9% and 37.4% of the baseline, respectively (P < 0.05). Effects were also seen in OCT and retinal histology starting within one week after the start of treatment and thereafter remaining stable.

CONCLUSION:

Pradofloxacin at 6 and 10 times the recommended doses was shown to have no retinal toxic effects in cats, neither on rod or cone function with ERG.

PMID:
17909874
DOI:
10.1007/s10633-007-9081-x
[PubMed - indexed for MEDLINE]
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