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Med Care. 2007 Oct;45(10 Supl 2):S50-7.

Practice-based evidence study design for comparative effectiveness research.

Author information

1
International Severity Information Systems, Inc.; and Institute for Clinical Outcomes Research, Salt Lake City, Utah, USA. shorn@isisicor.com

Abstract

OBJECTIVES:

To describe a new, rigorous, comprehensive practice-based evidence for clinical practice improvement (PBE-CPI) study methodology, and compare its features, advantages, and disadvantages to those of randomized controlled trials and sophisticated statistical methods for comparative effectiveness research.

RESEARCH DESIGN:

PBE-CPI incorporates natural variation within data from routine clinical practice to determine what works, for whom, when, and at what cost. It uses the knowledge of front-line caregivers, who develop study questions and define variables as part of a transdisciplinary team. Its comprehensive measurement framework provides a basis for analyses of significant bivariate and multivariate associations between treatments and outcomes, controlling for patient differences, such as severity of illness.

RESULTS:

PBE-CPI studies can uncover better practices more quickly than randomized controlled trials or sophisticated statistical methods, while achieving many of the same advantages. We present examples of actionable findings from PBE-CPI studies in postacute care settings related to comparative effectiveness of medications, nutritional support approaches, incontinence products, physical therapy activities, and other services.

CONCLUSIONS:

Outcomes improved when practices associated with better outcomes in PBE-CPI analyses were adopted in practice.

PMID:
17909384
DOI:
10.1097/MLR.0b013e318070c07b
[Indexed for MEDLINE]

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