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Antimicrob Agents Chemother. 2007 Dec;51(12):4525-8. Epub 2007 Oct 1.

Antileishmanial structure-activity relationships of synthetic phospholipids: in vitro and in vivo activities of selected derivatives.

Author information

1
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom. karin.seifert@lshtm.ac.uk

Abstract

Antileishmanial activities of 91 synthetic phospholipids against Leishmania donovani were evaluated in vitro and cytotoxicity assessed against two mammalian cell lines. Promising compounds were tested further in vivo. In vitro structure-activity relationships showed a positive contribution of head groups bearing ring systems (N-methylpiperidino and N-methylmorpholino) to antileishmanial activity.

PMID:
17908944
PMCID:
PMC2167978
DOI:
10.1128/AAC.00465-07
[Indexed for MEDLINE]
Free PMC Article

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