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Br J Psychiatry. 2007 Oct;191:355-6.

Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population.

Author information

1
Yale-New Haven Psychiatric Hospital, 184 Liberty Street LV108, New Haven, CT 06519, USA. ralph.hoffman@yale.edu

Abstract

Atendency to extract spurious, message-like meaning from meaningless noise was assessed as a risk factor leading to schizophrenia-spectrum disorders by assessing word length of speech illusions elicited by multispeaker babble in 43 people with prodromal symptoms. These individuals were randomised to olanzapine v. placebo groups during year 1 followed by no pharmacological treatment for those with no disorder conversion during year 2. A time-dependent Cox regression analysis of conversion to schizophrenia-spectrum disorder revealed a significant interaction between condition (olanzapine v. no drug) and length of speech illusion, with the latter strongly predicting subsequent conversion during medication-free intervals but not during olanzapine treatment.

PMID:
17906248
DOI:
10.1192/bjp.bp.106.031195
[Indexed for MEDLINE]

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